The Rabbit Anti-TBP/Tata Binding Protein Tbp Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to TATA-box binding protein, and TBP. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-TBP/Tata Binding Protein Tbp Antibody has been validated for the following applications: Western Blot.
Description
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA